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Dynamic Remodeling of Transcription Complexes by Molecular Chaperones

Overview
Journal Cell
Publisher Cell Press
Specialty Cell Biology
Date 2002 Aug 15
PMID 12176314
Citations 63
Authors
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Abstract

The assembly and disassembly of macromolecular transcription complexes represents a key step in the regulation of gene expression. For inducible responses to hormones and stress, different combinations of molecular chaperones govern the activities of intracellular hormone receptors and heat shock transcription factor. Through their capacity to remodel the conformation of these activators, chaperones ensure tight control, dynamic range, and rapid reversible transcriptional response.

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