Evidence from Twins for Acquired Cellular Immune Hyperactivity in Type 1 Diabetes

Overview

Journal Immunology

Specialty Allergy & Immunology

Date 2002 Aug 3

PMID 12153522

Citations 2

Authors

Nikolai Petrovsky

Kirsten O Kyvik

Vagn Bonnevie-Nielsen

Henning Beck-Nielsen

Anders Green

Leonard C Harrison

Affiliations

Soon will be listed here.

Abstract

Type 1 diabetes has been associated with an increased frequency of activated T cells and T-cell hyperactivity to non-specific and disease-specific stimuli including the islet autoantigen glutamic acid decarboxylase 65 (GAD). To address whether T-cell hyperactivity is genetic or acquired we measured whole blood cytokines in vitro in response to GAD or tetanus in 18 identical twin pairs, nine discordant for type 1 diabetes. In addition, the activity of 2', 5' oligoadenylate synthetase (OAS) in blood mononuclear cells was measured as a marker of viral infection. Interleukin-2 (IL-2) basally and IL-2 and interferon-gamma (IFN-gamma) in response to GAD, were detected more frequently and at higher levels in diabetic compared to non-diabetic twins. IL-10 was not different between groups. OAS activity was increased in diabetic compared to non-diabetic twins and showed a correlation with basal IL-2 and GAD-stimulated IFN-gamma and IL-10. These findings suggest that T-cell hyperactivity in type 1 diabetes is an acquired trait and could reflect persisting virus expression.

Citing Articles

Environmental determinants of islet autoimmunity (ENDIA): a pregnancy to early life cohort study in children at-risk of type 1 diabetes.

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T-helper cell tolerance to ubiquitous nuclear antigens.

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