A General Method for the Formation of Aryl-sulfur Bonds Using Copper(I) Catalysts

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2002 Aug 3

PMID 12153239

Citations 17

Authors

Craig G Bates

Rattan K Gujadhur

D Venkataraman

Affiliations

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Abstract

[reaction: see text] We report a mild, palladium-free synthetic protocol for the cross-coupling reaction of aryl iodides and thiols using 10 mol % CuI and 10 mol % neocuproine, with NaOt-Bu as the base, in toluene at 110 degrees C. Using this protocol, we have shown that a variety of aryl sulfides can be synthesized in excellent yields from readily available iodides and thiols.

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