Helicobacter Pylori SabA Adhesin in Persistent Infection and Chronic Inflammation

Overview

Journal Science

Specialty Science

Date 2002 Jul 27

PMID 12142529

Citations 362

Authors

Jafar Mahdavi

Berit Sonden

Marina Hurtig

Farzad O Olfat

Lina Forsberg

Niamh Roche

Jonas Angstrom

Thomas Larsson

Susann Teneberg

Karl-Anders Karlsson

Siiri Altraja

Torkel Wadstrom

Dangeruta Kersulyte

Douglas E Berg

Andre Dubois

Christoffer Petersson

Karl-Eric Magnusson

Thomas Norberg

Frank Lindh

Bertil B Lundskog

Anna Arnqvist

Lennart Hammarstrom

Thomas Boren

Affiliations

Soon will be listed here.

Abstract

Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H. pylori and show that H. pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid-binding adhesin (SabA) was isolated with the "retagging" method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H. pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H. pylori infection.

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