Renal Cell Carcinoma Metastatic to the Thyroid Gland: A Comparative Molecular Study Between the Primary and the Metastatic Tumor

Overview

Journal Endocr Pathol

Specialties Endocrinology
Pathology

Date 2002 Jul 13

PMID 12114717

Citations 1

Authors

Xavier Matias-Guiu

Arnald Garcia

Roma Curell

Jaime Prat

Affiliations

Soon will be listed here.

Abstract

A case of renal cell carcinoma metastatic to the thyroid gland is presented. The thyroid tumor showed typical features: clear cells arranged in nests with a prominent sinusoidal vascular pattern. The histologic appearance was identical to the renal tumor removed 6 yr before. A comparative molecular study between the primary and the metastatic tumor showed a common profile with a loss of heterozygosity at identical loci on chromosome 3, which provided further support to the metastatic nature of the thyroid tumor. However, the frequent existence of allele losses on chromosome 3p in both renal cell carcinomas and primary thyroid follicular carcinomas rest some force from such a molecular approach to the differential diagnosis of thyroid tumors that contain a predominant population of clear cells.

Citing Articles

Mixed medullary and follicular carcinoma of the thyroid. On the search for its histogenesis.

Matias-Guiu X Am J Pathol. 1999; 155(5):1413-8.

PMID: 10550294 PMC: 1866975. DOI: 10.1016/S0002-9440(10)65453-3.

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