Heat-Shock Stress-Response Proteins in Endocrine Pathology

Overview

Journal Endocr Pathol

Specialties Endocrinology
Pathology

Date 1995 Apr 1

PMID 12114685

Authors

George Kontogeorgos

Kalman Kovacs

Sylvia L Asa

Affiliations

Soon will be listed here.

Abstract

Heat-shock proteins (HSPs), also known as stress-response proteins, represent an evolutionarily conserved class of glycoproteins; members of this protein family are also known as "molecular chaperones." HSPs are constitutively expressed, and most are overproduced in response to a nonlethal thermal shock or other stressful conditions. They are implicated in several cell functions; they likely act in association with steroid receptors at the level of receptor-DNA interactions. Various types of HSPs have been found in endocrine glands, hormone-dependent tissues, and neoplasms. At present, their exact role remains obscure. HSPs may serve as tumor markers of prognostic significance; they may also have diagnostic and therapeutic uses.

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