The Otx Family

Overview

Journal Curr Opin Genet Dev

Publisher Elsevier

Specialties Biology
Genetics

Date 2002 Jul 9

PMID 12100885

Citations 38

Authors

Antonio Simeone

Eduardo Puelles

Dario Acampora

Affiliations

Soon will be listed here.

Abstract

Otx1 and Otx2, the murine homologs of the Drosophila orthodenticle gene, play a remarkable role in specification and regionalization of forebrain and midbrain. Recently, genetic approaches have indicated that OTD, OTX1 and OTX2 have retained reciprocal functional equivalence in evolution, whereas their regulatory control has been remarkably modified. This suggests that during the evolution of the vertebrate brain, regulatory changes modulating the transcriptional and translational control of pre-existing gene functions might have favored the establishment of new morphogenetic pathways.

Citing Articles

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Hypermethylation Loci of ZNF671, IRF8, and OTX1 as Potential Urine-Based Predictive Biomarkers for Bladder Cancer.

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Genes in Adult Tissues.

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The long non-coding RNA OTX2-AS1 promotes tumor growth and predicts response to BCL-2 inhibition in medulloblastoma.

Qin N, Paisana E, Picard D, Leprivier G, Langini M, Custodia C J Neurooncol. 2023; 165(2):329-342.

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An Update on the Molecular Mechanism of the Vertebrate Isthmic Organizer Development in the Context of the Neuromeric Model.

Hidalgo-Sanchez M, Andreu-Cervera A, Villa-Carballar S, Echevarria D Front Neuroanat. 2022; 16:826976.

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