Bradykinin-12-lipoxygenase-VR1 Signaling Pathway for Inflammatory Hyperalgesia

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2002 Jul 5

PMID 12097645

Citations 130

Authors

Jieun Shin

Hawon Cho

Sun Wook Hwang

Jooyoung Jung

Chan Young Shin

Soon-Youl Lee

So Hee Kim

Myung Gull Lee

Young Hae Choi

Jinwoong Kim

Nicole Alessandri Haber

David B Reichling

Sachia Khasar

Jon D Levine

Uhtaek Oh

Affiliations

Soon will be listed here.

Abstract

The capsaicin-sensitive vanilloid receptor (VR1) was recently shown to play an important role in inflammatory pain (hyperalgesia), but the underlying mechanism is unknown. We hypothesized that pain-producing inflammatory mediators activate capsaicin receptors by inducing the production of fatty acid agonists of VR1. This study demonstrates that bradykinin, acting at B2 bradykinin receptors, excites sensory nerve endings by activating capsaicin receptors via production of 12-lipoxygenase metabolites of arachidonic acid. This finding identifies a mechanism that might be targeted in the development of new therapeutic strategies for the treatment of inflammatory pain.

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