Intensity-dependent Effects of 1 Hz RTMS on Human Corticospinal Excitability

Overview

Journal Clin Neurophysiol

Publisher Elsevier

Specialties Neurology
Psychiatry

Date 2002 Jun 29

PMID 12088710

Citations 64

Authors

Paul B Fitzgerald

Timothy L Brown

Z Jeff Daskalakis

Robert Chen

J Kulkarni

Affiliations

Soon will be listed here.

Abstract

Objectives: This study explored whether the effects of repetitive transcranial magnetic stimulation (rTMS) on corticospinal excitability are dependent on the stimulation intensity and examined the effect of rTMS on inhibitory function.

Methods: Nine normal volunteers received 15min of 1Hz rTMS at 85 and 115% of the resting motor threshold (RMT). Cortical excitability was measured before and after rTMS.

Results: rTMS at both intensities produced an increase in the RMT but only 115% stimulation reduced the size of motor evoked potentials (MEPs). rTMS had no effects on the cortical silent period or cortical inhibition measured with paired pulse TMS.

Conclusions: The effects of 1Hz rTMS on motor cortex excitability are partially dependent on stimulus intensity and the effects of rTMS on motor thresholds and MEP size may differ.

Citing Articles

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Retest reliability of repetitive transcranial magnetic stimulation over the healthy human motor cortex: a systematic review and meta-analysis.

Kanig C, Osnabruegge M, Schwitzgebel F, Litschel K, Seiberl W, Mack W Front Hum Neurosci. 2023; 17:1237713.

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No effects of 1 Hz offline TMS on performance in the stop-signal game.

Friehs M, Siodmiak J, Donzallaz M, Matzke D, Numssen O, Frings C Sci Rep. 2023; 13(1):11565.

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Neuromodulatory effects and reproducibility of the most widely used repetitive transcranial magnetic stimulation protocols.

Magnuson J, Ozdemir M, Mathieson E, Kirkman S, Passera B, Rampersad S PLoS One. 2023; 18(6):e0286465.

PMID: 37352290 PMC: 10289434. DOI: 10.1371/journal.pone.0286465.