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Fibrinogen E Fragment Selectively Disrupts the Vasculature and Inhibits the Growth of Tumours in a Syngeneic Murine Model

Overview
Journal Br J Cancer
Specialty Oncology
Date 2002 Jun 28
PMID 12087471
Citations 8
Authors
N J Brown
C A Staton
G R Rodgers
K P Corke
J C E Underwood
C E Lewis
Affiliations
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Abstract

We recently demonstrated that a fragment of human fibrinogen, fibrinogen E fragment, inhibits the migration and differentiation of human endothelial cells in vitro. Here we show that it exerts similar effects on murine endothelial cells in vitro, and selectively disrupts tumour endothelium in vivo, causing widespread intravascular thrombosis and retarding the growth of CT26 tumours in a syngeneic murine model.

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