Aged Garlic Extract Therapy for Sickle Cell Anemia Patients

Overview

Journal BMC Blood Disord

Publisher Biomed Central

Specialty Hematology

Date 2002 Jun 28

PMID 12086586

Citations 2

Authors

Junichiro Takasu

Rolando Uykimpang

Maria Sunga

Harunobu Amagase

Yutaka Niihara

Affiliations

Soon will be listed here.

Abstract

BACKGROUND: Sickle cell anemia is one of the most prevalent hereditary disorders with prominent morbidity and mortality. With this disorder oxidative, phenomena play a significant role in its pathophysiology. One of the garlic (Allium sativum L.) formulations, aged garlic extract (AGE), has been reported to exert an anti-oxidant effect in vitro, we have evaluated the anti-oxidant effect of AGE on sickle red blood cells (RBC). METHODS: Five patients (two men and three women, mean age 40 &PlusMinus; 15 years, range 24-58 years) with sickle cell anemia participated in the study. AGE was administered at a dose of 5 ml a day. Whole blood samples were obtained at baseline and at 4 weeks for primarily Heinz body analysis. RESULTS: The data were consistent with our hypothesis. In all patients, the number of Heinz bodies decreased over the 4 week period (58.9 &PlusMinus; 20.0% at baseline to 29.8 &PlusMinus; 15.3% at follow-up, p = 0.03). CONCLUSIONS: These data suggest that there is a significant anti-oxidant activity of AGE on sickle RBC. AGE may be further evaluated as a potential therapeutic agent to ameliorate complications of sickle cell anemia.

Citing Articles

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The antioxidant mechanisms underlying the aged garlic extract- and S-allylcysteine-induced protection.

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