A Novel Method for the Analysis of the Androgen Receptor

Overview

Journal Curr Urol Rep

Publisher Current Science

Specialty Urology

Date 2002 Jun 27

PMID 12084222

Citations 2

Authors

Kris E Gaston

O Harris Ford III

Swaroop Singh

Christopher W Gregory

Donald E Weyel

Gary J Smith

James L Mohler

Affiliations

Soon will be listed here.

Abstract

The role of the androgen receptor in the regulation of prostate cancer development and progression has been a focus of intense research. Until recent years, the level of expression of the androgen receptor protein was described qualitatively. Immunohistochemical parameters have been established that show a linear relationship between androgen receptor expression and immunostaining. Intensity of immunostaining can be accurately measured using computer-assisted color video image analysis. Studies of progression and treatment of prostate cancer will benefit from the ability to quantitatively measure androgen receptor expression.

Citing Articles

A role for the androgen-receptor in clinically localized and advanced prostate cancer.

Mohler J Best Pract Res Clin Endocrinol Metab. 2008; 22(2):357-72.

PMID: 18471792 PMC: 2799036. DOI: 10.1016/j.beem.2008.01.009.

Java Web Start based software for automated quantitative nuclear analysis of prostate cancer and benign prostate hyperplasia.

Singh S, Kim D, Mohler J Biomed Eng Online. 2005; 4:31.

PMID: 15888205 PMC: 1145186. DOI: 10.1186/1475-925X-4-31.

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