Study on the Components of Luobuma with Peroxynitrite-scavenging Activity

Overview

Journal Biol Pharm Bull

Specialty Biochemistry

Date 2002 Jun 26

PMID 12081141

Citations 11

Authors

Takako Yokozawa

Yoshiki Kashiwada

Masao Hattori

Hae Young Chung

Affiliations

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Abstract

The origin of the antioxidant activity of Luobuma aqueous extract was examined by measuring the peroxynitrite (ONOO-)-eliminating activities of fractions of this extract obtained by Sephadex LH-20 column chromatography. Three of the four fractions obtained, i.e., those excluding the H2O-eluted fraction, were found to possess (ONOO-)-eliminating activity. These three fractions were combined and fractionated again by Sephadex LH-20 column chromatography, which yielded five fractions. Seven different compounds were isolated from two of these five fractions with high activity. Epigallocatechin-(4beta-8)-epicatechin showed the highest (ONOO-)-eliminating activity.

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