Total Synthesis of (+/-)-O-methyl PD 116740
Overview
Chemistry
Affiliations
[reaction: see text] Condensation of the phthalide sulfide with an ortho-quinone monoketal was employed as a key step in the first total synthesis of a derivative of (+/-)-PD 116740.
Himalaquinones A-G, Angucyclinone-Derived Metabolites Produced by the Himalayan Isolate sp. PU-MM59.
Zhang Y, Cheema M, Ponomareva L, Ye Q, Liu T, Sajid I J Nat Prod. 2021; 84(7):1930-1940.
PMID: 34170698 PMC: 8565601. DOI: 10.1021/acs.jnatprod.1c00192.
Angucycline Glycosides from Mangrove-Derived subsp. SCSIO GJ056.
Gui C, Liu Y, Zhou Z, Zhang S, Hu Y, Gu Y Mar Drugs. 2018; 16(6).
PMID: 29843358 PMC: 6025406. DOI: 10.3390/md16060185.