Degradation of Immunoglobulins, Protease Inhibitors and Interleukin-1 by a Secretory Proteinase of Acanthamoeba Castellanii

Overview

Journal Korean J Parasitol

Specialty Parasitology

Date 2002 Jun 21

PMID 12073735

Citations 9

Authors

Byoung-Kuk Na

Jung-Hwa Cho

Chul-Yong Song

Tong-Soo Kim

Affiliations

Soon will be listed here.

Abstract

The effect of a secretory proteinase from the pathogenic amoebae Acanthamoeba castellanii on host's defense-oriented or regulatory proteins such as immunoglobulins, interleukin-1, and protease inhibitors was investigated. The enzyme was found to degrade secretory immunoglobulin A (sIgA), IgG, and IgM. It also degraded interleukin-1 alpha (IL-1 alpha) and IL-1 beta. Its activity was not inhibited by endogenous protease inhibitors, such as alpha 2-macroglobulin, alpha 1-trypsin inhibitor, and alpha 2-antiplasmin. Furthermore, the enzyme rapidly degraded those endogenous protease inhibitors as well. The degradation of host's defense-oriented or regulatory proteins by the Acanthamoeba proteinase suggested that the enzyme might be an important virulence factor in the pathogenesis of Acanthamoeba infection.

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References

Leher H, Alizadeh H, Taylor W, Shea A, Silvany R, Van Klink F . Role of mucosal IgA in the resistance to Acanthamoeba keratitis. Invest Ophthalmol Vis Sci. 1998; 39(13):2666-73. View

Van Klink F, Leher H, Jager M, Alizadeh H, Taylor W, Niederkorn J . Systemic immune response to Acanthamoeba keratitis in the Chinese hamster. Ocul Immunol Inflamm. 1998; 5(4):235-44. DOI: 10.3109/09273949709085064. View

Leher H, Silvany R, Alizadeh H, Huang J, Niederkorn J . Mannose induces the release of cytopathic factors from Acanthamoeba castellanii. Infect Immun. 1998; 66(1):5-10. PMC: 107851. DOI: 10.1128/IAI.66.1.5-10.1998. View

Na B, Kim J, Song C . Characterization and pathogenetic role of proteinase from Acanthamoeba castellanii. Microb Pathog. 2001; 30(1):39-48. DOI: 10.1006/mpat.2000.0403. View

Laemmli U . Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970; 227(5259):680-5. DOI: 10.1038/227680a0. View

ALLANSMITH M, de Ramus A, Maurice D . The dynamics of IgG in the cornea. Invest Ophthalmol Vis Sci. 1979; 18(9):947-55. View

Gachon A, Richard J, Dastugue B . Human tears: normal protein pattern and individual protein determinations in adults. Curr Eye Res. 1982; 2(5):301-8. DOI: 10.3109/02713688209000774. View

WELLS P, Hazlett L . Immunocytochemical localization of immunoglobulins at the corneal surface of the mouse. Exp Eye Res. 1985; 40(6):779-96. DOI: 10.1016/0014-4835(85)90123-x. View

Mestecky J, Russell M, Jackson S, Brown T . The human IgA system: a reassessment. Clin Immunol Immunopathol. 1986; 40(1):105-14. DOI: 10.1016/0090-1229(86)90073-5. View

10.

Gregory R, ALLANSMITH M . Naturally occurring IgA antibodies to ocular and oral microorganisms in tears saliva and colostrum: evidence for a common mucosal immune system and local immune response. Exp Eye Res. 1986; 43(5):739-49. DOI: 10.1016/s0014-4835(86)80005-7. View

11.

Mathers W, Stevens Jr G, Rodrigues M, Chan C, Gold J, Visvesvara G . Immunopathology and electron microscopy of Acanthamoeba keratitis. Am J Ophthalmol. 1987; 103(5):626-35. DOI: 10.1016/s0002-9394(14)74321-1. View

12.

McKerrow J . Parasite proteases. Exp Parasitol. 1989; 68(1):111-5. DOI: 10.1016/0014-4894(89)90016-7. View

13.

Silvany R, Dougherty J, McCulley J, Wood T, Bowman R, Moore M . The effect of currently available contact lens disinfection systems on Acanthamoeba castellanii and Acanthamoeba polyphaga. Ophthalmology. 1990; 97(3):286-90. DOI: 10.1016/s0161-6420(90)32590-3. View

14.

Fullard R, Snyder C . Protein levels in nonstimulated and stimulated tears of normal human subjects. Invest Ophthalmol Vis Sci. 1990; 31(6):1119-26. View

15.

Hazlett L, Berk R . Kinetics of immunoglobulin appearance at the ocular surface. Reg Immunol. 1989; 2(5):294-9. View

16.

He Y, Niederkorn J, McCulley J, Stewart G, MEYER D, Silvany R . In vivo and in vitro collagenolytic activity of Acanthamoeba castellanii. Invest Ophthalmol Vis Sci. 1990; 31(11):2235-40. View

17.

Niederkorn J, Ubelaker J, McCulley J, Stewart G, MEYER D, Mellon J . Susceptibility of corneas from various animal species to in vitro binding and invasion by Acanthamoeba castellanii [corrected]. Invest Ophthalmol Vis Sci. 1992; 33(1):104-12. View

18.

Van Klink F, Alizadeh H, He Y, Mellon J, Silvany R, McCulley J . The role of contact lenses, trauma, and Langerhans cells in a Chinese hamster model of Acanthamoeba keratitis. Invest Ophthalmol Vis Sci. 1993; 34(6):1937-44. View

19.

Mitro K, Bhagavathiammai A, Zhou O, Bobbett G, McKerrow J, Chokshi R . Partial characterization of the proteolytic secretions of Acanthamoeba polyphaga. Exp Parasitol. 1994; 78(4):377-85. DOI: 10.1006/expr.1994.1041. View

20.

Dinarello C . The biological properties of interleukin-1. Eur Cytokine Netw. 1994; 5(6):517-31. View