CD83 on Dendritic Cells: More Than Just a Marker for Maturation

Overview

Journal Trends Immunol

Specialty Allergy & Immunology

Date 2002 Jun 20

PMID 12072358

Citations 76

Authors

Matthias Lechmann

Susanne Berchtold

Joachim Hauber

Alexander Steinkasserer

Affiliations

Soon will be listed here.

Abstract

CD83 has been known for a long time to be one of the best markers for mature dendritic cells (DCs). Studies with herpes simplex virus type 1 (HSV-1)-infected DCs, whereby the viral infection leads to the degradation of CD83, as well as investigations inhibiting CD83 mRNA transport, have provided evidence that CD83 might also be important for DC biology. Recently, we have shown that the soluble extracellular CD83 domain inhibits DC-mediated T-cell proliferation, representing the first report describing a functional role for CD83.

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