Bioactive Steroids from the Brown Alga Sargassum Carpophyllum

Overview

Journal J Asian Nat Prod Res

Publisher Informa Healthcare

Specialties Biology
Chemistry

Date 2002 Jun 18

PMID 12067165

Citations 21

Authors

Hai-Feng Tang

Xin-Sheng Yao

Qiang-Zhi Xu

Shu-Yu Zhang

Hou-Wen Lin

Affiliations

Soon will be listed here.

Abstract

By activity-guided fractionation, two new sterols, 3beta,28xi-dihydroxy-24-ethylcholesta-5,23Z-dien (1) and 2a-oxa-2-oxo-5alpha-hydroxy-3,4-dinor-24-ethylcholesta-24(28)-ene (2), together with five known steroids, fucosterol (3), 24-ethylcholesta-4,24(28)-dien-3,6-dione (4), 24xi-hydroperoxy-24-vinylcholesterol (5), 24-ketocholesterol (6), 24R,28R- and 24S, 28S-epoxy-24-ethylcholesterol (7), were isolated from the brown alga Sargassum carpophyllum as active compounds causing morphological abnormality of Pyricularia oryzae mycelia. Compounds 1, 3, 4, 5 and 7 also exhibited cytotoxic activity against various cancer cell lines. The IC50 values for 1 and 5 against HL-60 were 7.8 and 8.5 microg/ml, 3 and 4 against P-388 were 0.7 and 0.8 microg/ml, whereas 7 against MCF-7, HCT-8, 1A9, HOS and PC-3 were 4.0, 8.8, 10.0, 10.0 and 7.2 microg/ml, respectively.

Citing Articles

Diversified Chemical Structures and Bioactivities of the Chemical Constituents Found in the Brown Algae Family Sargassaceae.

Peng Y, Yang X, Huang R, Ren B, Chen B, Liu Y Mar Drugs. 2024; 22(2).

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In Vitro Anti-Oxidant, In Vivo Anti-Hyperglycemic, and Untargeted Metabolomics-Aided-In Silico Screening of Macroalgae Lipophilic Extracts for Anti-Diabetes Mellitus and Anti-COVID-19 Potential Metabolites.

Sunarwidhi A, Rahmaniar W, Prasedya E, Padmi H, Widyastuti S, Pangestu K Metabolites. 2023; 13(12).

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Identification of Side Chain Oxidized Sterols as Novel Liver X Receptor Agonists with Therapeutic Potential in the Treatment of Cardiovascular and Neurodegenerative Diseases.

Zhan N, Wang B, Martens N, Liu Y, Zhao S, Voortman G Int J Mol Sci. 2023; 24(2).

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Effect of the Extract on Methamphetamine-Induced Cytotoxicity in SH-SY5Y Cells.

Salari Z, Abbasnejad M, Askari Hesni M, Esmaeili-Mahani S Evid Based Complement Alternat Med. 2022; 2022:9978235.

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Extraction and Fractionation of the Seaweed and Evaluation of Fractions on Depression Induced by Interferon Alpha in Mice.

Mesripour A, Gholamzadeh E, Yegdaneh A Adv Biomed Res. 2022; 11:59.

PMID: 36124020 PMC: 9482374. DOI: 10.4103/abr.abr_186_21.