Absence of Cellular Hypersensitivity to Muscle and Thymic Antigens in Myasthenia Gravis

Overview

Journal J Neurol Neurosurg Psychiatry

Publisher BMJ Publishing Group

Specialties Neurology
Neurosurgery
Psychiatry

Date 1975 Nov 1

PMID 1206412

Citations 5

Authors

W M Behan

P O Behan

J A Simpson

Affiliations

Soon will be listed here.

Abstract

Humoral antibodies to skeletal muscle and its components and to thymus have been demonstrated in the sera of patients with myasthenia gravis. A role for cellular hypersensitivity to similar antigens in the pathogenesis of the disease has been suggested by some reports of the presence of cellular immunity. A detailed immunological study using muscle and thymic antigens, including those prepared from the patients' own tissues, failed to confirm these findings. It is suggested that previous reports of cellular hypersensitivity represent the demonstration of an epiphenomenon.

Citing Articles

Association of myasthenia gravis and polymyositis with neoplasia, infection and autoimmune disorders.

Behan W, Behan P, Doyle D Acta Neuropathol. 1982; 57(2-3):221-9.

PMID: 6751015 DOI: 10.1007/BF00685393.

Does Toxoplasma cause polymyositis? Report of a case of polymyositis associated with toxoplasmosis and a critical review of the literature.

Behan W, Behan P, Draper I, Williams H Acta Neuropathol. 1983; 61(3-4):246-52.

PMID: 6650138 DOI: 10.1007/BF00691993.

Immunological features of polymyositis/dermatomyositis.

Behan W, Behan P Springer Semin Immunopathol. 1985; 8(3):267-93.

PMID: 3901370 DOI: 10.1007/BF00197300.

Phenotypic and functional analysis of lymphocytes in myasthenia gravis.

Levinson A, Lisak R, Zweiman B, Kornstein M Springer Semin Immunopathol. 1985; 8(3):209-33.

PMID: 3901367 DOI: 10.1007/BF00197297.

Cellular autoimmunity to muscle: a review.

Esiri M Proc R Soc Med. 1977; 70(5):330-2.

PMID: 327480 PMC: 1543074.

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