The Biosynthetic Pathway for Lipoic Acid is Present in Plastids and Mitochondria in Arabidopsis Thaliana

Overview

Journal FEBS Lett

Specialty Biochemistry

Date 2002 Jun 14

PMID 12062419

Citations 30

Authors

Rie Yasuno

Hajime Wada

Affiliations

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Abstract

In eukaryotes, the biosynthetic pathway for lipoic acid is present in mitochondria. However, it has been hypothesized that, in plants, the biosynthetic pathway is present in plastids in addition to mitochondria. In this study, Arabidopsis thaliana LIP1p cDNA for a plastidial form of lipoic acid synthase has been identified. We show that it encodes a lipoic acid synthase by demonstrating its ability to complement an Escherichia coli mutant lacking lipoic acid synthase activity. We also show that LIP1p is targeted to chloroplasts. These findings suggest that the biosynthetic pathway for lipoic acid is present not only in mitochondria but also in plastids.

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