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Novel CDNAs Encoding Salivary Proteins from the Malaria Vector Anopheles Gambiae

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Journal FEBS Lett
Specialty Biochemistry
Date 2002 Jun 14
PMID 12062411
Citations 31
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Abstract

Several genes encoding salivary components of the mosquito Anopheles gambiae were identified using a selective trapping approach. Among these, five corresponded to genes expressed specifically in female glands and their role may possibly be linked to blood-feeding. Our collection included a fourth member of the D7 protein family and two polypeptides that showed weak similarity to anti-coagulants from distantly related species. Moreover, we identified two additional members of a novel group of proteins that we named glandins. The isolation of tissue-specific genes represents a first step toward a deeper molecular analysis of mosquito salivary secretions.

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