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Cobalt-catalyzed Heck-type Reaction of Alkyl Halides with Styrenes

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Journal J Am Chem Soc
Specialty Chemistry
Date 2002 Jun 6
PMID 12047154
Citations 20
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Abstract

A cobalt complex, CoCl2[1,6-bis(diphenylphosphino)hexane], catalyzes an alkylation reaction of styrenes in the presence of Me3SiCH2MgCl in ether to yield beta-alkylstyrenes. A variety of alkyl halides including alkyl chlorides can be employed as an alkyl source. A radical mechanism is strongly suggested for this alkylation reaction.

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