» Articles » PMID: 12037233

Sleep Disordered Breathing and Pregnancy

Overview
Journal Thorax
Date 2002 May 31
PMID 12037233
Citations 28
Authors
Affiliations
Soon will be listed here.
Abstract

Many changes in the respiratory system occur during pregnancy, particularly during the third trimester, which can alter respiratory function during sleep, increasing the incidence and severity of sleep disordered breathing. These changes include increased ventilatory drive and metabolic rate, reduced functional residual capacity and residual volume, increased alveolar-arterial oxygen gradients, and changes in upper airway patency. The clinical importance of these changes is indicated by the increased incidence of snoring during pregnancy, which is likely also to reflect an increased incidence of obstructive sleep apnoea/hypopnoea syndrome. For the respiratory physician asked to review a pregnant patient, the possibility of sleep disordered breathing should always be considered. This review first examines the normal physiological changes of pregnancy and their relationship to sleep disordered breathing, and then summarises the current knowledge of sleep disordered breathing in pregnancy.

Citing Articles

The Interplay Between Sleep Apnea and Postpartum Depression.

Maniaci A, La Via L, Lentini M, Pecorino B, Chiofalo B, Scibilia G Neurol Int. 2025; 17(2).

PMID: 39997651 PMC: 11858767. DOI: 10.3390/neurolint17020020.


A Relation between Obstructive Sleep Apnea in Pregnancy and Delivering Small for Gestational Age Infant-A Systematic Review.

Grajczyk A, Dzaman K, Czerwaty K, Kasperczak M, Zgliczynska M, Stepien A J Clin Med. 2023; 12(18).

PMID: 37762913 PMC: 10532405. DOI: 10.3390/jcm12185972.


Gestational chronic intermittent hypoxia induces hypertension, proteinuria, and fetal growth restriction in mice.

Weng C, Huang L, Feng H, He Q, Lin X, Jiang T Sleep Breath. 2021; 26(4):1661-1669.

PMID: 34845629 DOI: 10.1007/s11325-021-02529-3.


A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows.

Cerritelli F, Frasch M, Antonelli M, Viglione C, Vecchi S, Chiera M Front Neurosci. 2021; 15:721605.

PMID: 34616274 PMC: 8488382. DOI: 10.3389/fnins.2021.721605.


Impact of nasal dilator strips on measures of sleep-disordered breathing in pregnancy.

Maxwell M, Sanapo L, Monteiro K, Bublitz M, Avalos A, Habr N J Clin Sleep Med. 2021; 18(2):477-483.

PMID: 34432628 PMC: 8804998. DOI: 10.5664/jcsm.9624.


References
1.
LYONS H . Centrally acting hormones and respiration. Pharmacol Ther B. 1976; 2(4):743-51. DOI: 10.1016/0306-039x(76)90076-3. View

2.
Craig D, Toole M . Airway closure in pregnancy. Can Anaesth Soc J. 1975; 22(6):665-72. DOI: 10.1007/BF03013314. View

3.
Awe R, Nicotra M, Newsom T, Viles R . Arterial oxygenation and alveolar-arterial gradients in term pregnancy. Obstet Gynecol. 1979; 53(2):182-6. View

4.
Weinberger S, Weiss S, Cohen W, Weiss J, Johnson T . Pregnancy and the lung. Am Rev Respir Dis. 1980; 121(3):559-81. DOI: 10.1164/arrd.1980.121.3.559. View

5.
Haponik E, Smith P, Bohlman M, Allen R, Goldman S, Bleecker E . Computerized tomography in obstructive sleep apnea. Correlation of airway size with physiology during sleep and wakefulness. Am Rev Respir Dis. 1983; 127(2):221-6. DOI: 10.1164/arrd.1983.127.2.221. View