Liquid-phase Combinatorial Synthesis of Alicyclic Beta-lactams Via Ugi Four-component Reaction

Overview

Journal Org Lett

Publisher American Chemical Society

Specialties Biochemistry
Chemistry

Date 2002 May 25

PMID 12027659

Citations 13

Authors

Szilvia Gedey

Johan Van der Eycken

Ferenc Fulop

Affiliations

Soon will be listed here.

Abstract

[reaction: see text] Alicyclic beta-lactams were successfully synthesized via a parallel liquid-phase Ugi four-center three-component reaction (U-4C-3CR), starting from alicyclic beta-amino acids such as cis-2-aminocyclohexanecarboxylic acid, cis-2-aminocyclopentanecarboxylic acid, 2,3-diexo-3-aminobicyclo[2.2.1]heptane-2-carboxylic acid and some of their partially unsaturated analogues. A six-membered mixture-based combinatorial library of beta-lactams was also generated.

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