Increased Amount of Type III PN-collagen in AAA when Compared with AOD

Overview

Journal Eur J Vasc Endovasc Surg

Publisher Elsevier

Specialties Cardiology & Vascular Diseases
Gastroenterology
General Surgery

Date 2002 May 25

PMID 12027468

Citations 4

Authors

M K Bode

M Mosorin

J Satta

L Risteli

T Juvonen

J Risteli

Affiliations

Soon will be listed here.

Abstract

Objective: the extent of the processing of type III procollagen to type III collagen was determined in nine human abdominal aortic aneurysms (AAA), and compared with ten samples of aortoiliac occlusive disease (AOD).

Methods: the aminoterminal propeptide (PIIINP) and telopeptide (IIINTP) of type III procollagen and collagen, respectively, were immunologically measured in the soluble and insoluble fractions of the extracellular matrix. The assay for PIIINP in the insoluble matrix was further validated.

Results: the insoluble matrices of AAAs contained at least 12 times more incompletely processed type III pN-collagen than AOD specimens (0.74% and 0.061%, respectively). Also, the soluble extracts of AAAs tended to contain more non-processed type III pN-collagen than free, properly cleaved aminoterminal propeptide.

Conclusions: the larger amount of type III pN-collagen suggests an alteration in the metabolism of type III collagen in AAAs. This may partially explain the decreased tensile strength of the aortic tissue.

Citing Articles

Diagnosis and monitoring of abdominal aortic aneurysm: current status and future prospects.

Moxon J, Parr A, Emeto T, Walker P, Norman P, Golledge J Curr Probl Cardiol. 2010; 35(10):512-48.

PMID: 20932435 PMC: 3014318. DOI: 10.1016/j.cpcardiol.2010.08.004.

Circulating markers of abdominal aortic aneurysm presence and progression.

Golledge J, Tsao P, Dalman R, Norman P Circulation. 2008; 118(23):2382-92.

PMID: 19047592 PMC: 2752737. DOI: 10.1161/CIRCULATIONAHA.108.802074.

Upregulation of protein kinase cdelta in vascular smooth muscle cells promotes inflammation in abdominal aortic aneurysm.

Schubl S, Tsai S, Ryer E, Wang C, Hu J, Kent K J Surg Res. 2008; 153(2):181-7.

PMID: 18952226 PMC: 3322540. DOI: 10.1016/j.jss.2008.04.032.

Turning back the clock: regression of abdominal aortic aneurysms via pharmacotherapy.

Aoki H, Yoshimura K, Matsuzaki M J Mol Med (Berl). 2007; 85(10):1077-88.

PMID: 17522832 DOI: 10.1007/s00109-007-0213-2.