Database of Bronchoalveolar Lavage Fluid Proteins

Overview

Journal J Chromatogr B Analyt Technol Biomed Life Sci

Publisher Elsevier

Specialties Biomedical Engineering
Chemistry

Date 2002 May 23

PMID 12016001

Citations 30

Authors

Isabelle Noel-Georis

Alfred Bernard

Paul Falmagne

Ruddy Wattiez

Affiliations

Soon will be listed here.

Abstract

Bronchoalveolar lavage during fiberoptic bronchoscopy is extensively used for investigating cellular and biochemical alterations of the epithelial lining fluid in various lung disorders. Two-dimensional electrophoresis (2-DE) offers the possibility to simultaneously display and analyze proteins contained in bronchoalveolar lavage fluid (BALF). We present the current status of 2-DE of BALF samples with an updated listing of the proteins already identified and of their level and/or posttranslational alterations in lung disorders. Alternatives to 2-DE of BALF samples and future prospects of proteomics to unravel lung functions and pathologies are discussed.

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