The Study of CTLA-4 and Vitamin D Receptor Polymorphisms in the Romanian Type 1 Diabetes Population

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2002 May 11

PMID 12003670

Citations 12

Authors

C Guja

S Marshall

K Welsh

M Merriman

A Smith

J A Todd

C Ionescu-Tirgoviste

Affiliations

Soon will be listed here.

Abstract

Several studies suggested that part of the genetic susceptibility for Type 1 diabetes (T1DM) is encoded by some polymorphisms of CTLA-4 gene (2q33) and of Vitamin D Receptor gene (VDR; 12q12-14). Our aim was to assess their contribution to T1DM genetic susceptibility in the Romanian population. We typed CTLA-4 49 A/G and VDR FokI (F/f), ApaI (A/a) and TaqI (T/t) polymorphisms by Sequence Specific Primer PCR (SSP-PCR) in 204 Romanian diabetic families (756 individuals: 212 T1DM probands and 544 unaffected parents and siblings). We studied alleles transmission using the Transmission Disequilibrium Test (TDT). We found an increased transmission of CTLA-4 49G allele to diabetics (54.8%, p=0.11). The transmission of F (56.1%, p=0.063), a (55.7%, p=0.061) and T (51.8%, p=0.37) alleles of VDR gene to diabetics was increased but did not reach statistical significance. In conclusion we found the same increased transmission of CTLA-4 49 G allele to diabetics as previously reported. VDR FoqI F allele seems to be predisposing while TaqI T allele seems to be protective.

Citing Articles

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Immunogenetic Prediction of VDR Gene SNPs: Lack of Association with Susceptibility to Type 1 Diabetes in Jordanian Patients.

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Vitamin D Receptor Gene Polymorphisms Influence T1D Susceptibility among Pakistanis.

Mukhtar M, Batool A, Wajid A, Qayyum I Int J Genomics. 2018; 2017:4171254.

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Inherited Variation in Vitamin D Genes and Type 1 Diabetes Predisposition.

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Impact of vitamin D receptor gene polymorphisms in pathogenesis of Type-1 diabetes mellitus.

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