Liver Alcohol Dehydrogenase in Japanese: High Population Frequency of Atypical Form and Its Possible Role in Alcohol Sensitivity

Overview

Journal Am J Hum Genet

Publisher Cell Press

Specialty Genetics

Date 1975 Nov 1

PMID 1200030

Citations 41

Authors

G Stamatoyannopoulos

S H Chen

M Fukui

Affiliations

Soon will be listed here.

Abstract

Electrophoretic and quantitative studies reveal that 85% of Japanese carry an atypical liver alcohol dehydrogenase (ADH). The frequency of ADH polymorphism is identical with the reported frequency of alcohol sensitivity in the Japanese population. This identity in population frequencies points to a causative relationship between the two phenomena and suggests that alcohol sensitivity might be due to the increased acetaldehyde formation in individuals carrying the atypical ADH gene.

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