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T-cell Prolymphocytic Leukemia with Hemorrhagic Gastrointestinal Involvement and a New Chromosomal Abnormality

Overview
Journal Int J Hematol
Specialty Hematology
Date 2002 May 10
PMID 11999363
Citations 5
Authors
Shigeo Toyota
Norihiko Nakamura
Kazuo Dan
Affiliations
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Abstract

We report a case of T-cell prolymphocytic leukemia in a 56-year-old woman who exhibited hemorrhaging with gastric involvement as the first manifestation. This patient's condition was diagnosed as T-cell prolymphocytic leukemia based on the findings of lymphocytosis, abnormal immunophenotype, hepatosplenomegaly, lymphadenopathy, and cutaneous involvement. Endoscopic examination of the upper gastrointestinal tract revealed hemorrhage from a gastric lesion with histological involvement. Cytogenetic analysis revealed chromosomal abnormalities, 46,XX,der(1), add(1)(p36), that have not previously been described in T-cell prolymphocytic leukemia. In spite of a transient response to chemotherapy, the patient died 15 months after onset of the disease.

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