Excess Mortality Associated with Antimicrobial Drug-resistant Salmonella Typhimurium

Overview

Journal Emerg Infect Dis

Specialty Infectious Diseases

Date 2002 May 9

PMID 11996684

Citations 92

Authors

Morten Helms

Pernille Vastrup

Peter Gerner-Smidt

Kare Molbak

Affiliations

Soon will be listed here.

Abstract

In a matched cohort study, we determined the death rates associated with drug resistance in Salmonella Typhimurium. We linked data from the Danish Surveillance Registry for Enteric Pathogens with the Civil Registration System and the Danish National Discharge Registry. By survival analysis, the 2-year death rates were compared with a matched sample of the general Danish population, after the data were adjusted for differences in comorbidity. In 2,047 patients with S. Typhimurium, 59 deaths were identified. Patients with pansusceptible strains of S. Typhimurium were 2.3 times more likely to die 2 years after infection than persons in the general Danish population. Patients infected with strains resistant to ampicillin, chloramphenicol, streptomycin, sulfonamide, and tetracycline were 4.8 times (95% CI 2.2 to 10.2) more likely to die, whereas quinolone resistance was associated with a mortality rate 10.3 times higher than the general population.

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