Proteases and the Biology of Glioma Invasion

Overview

Journal J Neurooncol

Publisher Springer

Date 2002 May 9

PMID 11995816

Citations 19

Authors

Devin K Binder

Mitchel S Berger

Affiliations

Soon will be listed here.

Abstract

Despite optimal clinical treatment, the prognosis for malignant gliomas remains poor. One of the primary reasons for treatment failure is not diffuse dissemination, but local invasion. Recently, there has been an increase in information regarding specific molecules that determine the aggressiveness and invasion potential of high-grade astrocytic tumors. In particular, expression of matrix metalloproteases in high-grade gliomas appears to correlate with tissue invasiveness. It is the purpose of the present review to describe the connection between alterations in growth-related genes, protease activity, and tumor biology, and how these connections may suggest potential novel therapeutic targets.

Citing Articles

Cuproptosis key gene FDX1 is a prognostic biomarker and associated with immune infiltration in glioma.

Lu H, Zhou L, Zhang B, Xie Y, Yang H, Wang Z Front Med (Lausanne). 2022; 9:939776.

PMID: 36523779 PMC: 9745336. DOI: 10.3389/fmed.2022.939776.

Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas.

Higgins D, Caliva M, Schroeder M, Carlson B, Upadhyayula P, Milligan B BMC Cancer. 2020; 20(1):1213.

PMID: 33302912 PMC: 7727139. DOI: 10.1186/s12885-020-07694-4.

Loss of SPINT2 expression frequently occurs in glioma, leading to increased growth and invasion via MMP2.

Pereira M, Celeiro S, Costa A, Pinto F, Popov S, de Almeida G Cell Oncol (Dordr). 2019; 43(1):107-121.

PMID: 31701492 DOI: 10.1007/s13402-019-00475-7.

Author Correction: Genetically engineered cerebral organoids model brain tumor formation.

Bian S, Repic M, Guo Z, Kavirayani A, Burkard T, Bagley J Nat Methods. 2018; 15(9):748.

PMID: 30135560 PMC: 6345371. DOI: 10.1038/s41592-018-0118-8.

Genetically engineered cerebral organoids model brain tumor formation.

Bian S, Repic M, Guo Z, Kavirayani A, Burkard T, Bagley J Nat Methods. 2018; 15(8):631-639.

PMID: 30038414 PMC: 6071863. DOI: 10.1038/s41592-018-0070-7.

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