Endothelial Progenitor Cells for Vascular Regeneration

Overview

Journal J Hematother Stem Cell Res

Specialties Cell Biology
Hematology

Date 2002 May 2

PMID 11983091

Citations 36

Authors

Takayuki Asahara

Jeffrey M Isner

Affiliations

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Abstract

The basis for native as well as therapeutic neovascularization is not restricted to angiogenesis but includes postnatal vasculogenesis. Our laboratory and others' have established that bone marrow-derived endothelial progenitor cells (EPCs) are present in the systemic circulation, are augmented in response to certain cytokines and/or tissue ischemia, and home to as well as incorporate into sites of neovascularization. Given the background, EPCs have been investigated as therapeutic agents in these studies of supply-side angiogenesis under pathological as well as physiological conditions. This review discusses the therapeutic potential of EPCs for cardiovascular ischemic diseases.

Citing Articles

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