The Sterol-sensing Domain: Multiple Families, a Unique Role?

Overview

Journal Trends Genet

Specialty Genetics

Date 2002 Apr 5

PMID 11932020

Citations 110

Authors

Patricia E Kuwabara

Michel Labouesse

Affiliations

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Abstract

The "sterol-sensing domain" (SSD) is conserved across phyla and is present in several membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the protein defective in Niemann-Pick type C1 disease). The role of the SSD is perhaps best understood from the standpoint of its involvement in cholesterol homeostasis. This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis.

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