Antidepressant Side Effects in Depression Patients Treated in a Naturalistic Setting: a Study of Bupropion, Moclobemide, Paroxetine, Sertraline, and Venlafaxine

Overview

Journal Can J Psychiatry

Specialty Psychiatry

Date 2002 Apr 3

PMID 11926080

Citations 33

Authors

J D Vanderkooy

Sidney H Kennedy

R Michael Bagby

Affiliations

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Abstract

Objective: There is no commonly accepted standard for comparing antidepressant-induced side effects. This study evaluates a clinician-administered scale, the Toronto Side Effect Scale (TSES), in a natural practice clinic.

Method: We used the TSES to assess side effects in 193 depression patients who completed 8 weeks of treatment with either bupropion, moclobemide, paroxetine, sertraline, or venlafaxine.

Results: Rates of remission (Hamilton Rating Scale for Depression [HRSD] < 7) did not differ across drugs after 8 weeks of treatment. Paired drug comparisons yielded significant differences in 16 of the 32 side effects. We present differences between pairs of the 5 antidepressants in Central Nervous System (CNS), gastrointestinal (GI), and sexual side effects. A measure of side-effect intensity distinguished paroxetine from the other antidepressants on a measure of sexual dysfunction.

Conclusions: These results confirm the clinical utility of the TSES as a simple, clinician-administered antidepressant side-effect scale.

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