Ruminal Metabolism in Sheep of Saponins from Yucca Schidigera

Overview

Journal Vet Res Commun

Publisher Springer

Specialty Veterinary Medicine

Date 2002 Apr 2

PMID 11922485

Citations 2

Authors

A Flaoyen

A L Wilkins

M Sandvik

Affiliations

Soon will be listed here.

Abstract

Fifty-five mg per kg live weight of crystallized Yucca schidigera saponins, corresponding to 26 mg/kg live weight of sapogenins, was given daily intraruminally to two lambs for 11 consecutive days. Neither of the lambs showed any sign of toxicity throughout the experimental period. One lamb was killed 5 h after the last dose and GC-MS analysis of the free and conjugated sapogenin content samples of liver, and of the contents of the rumen, omasum, abomasum, duodenum, jejunum, ileum, colon and rectum, of faecal samples collected before dosing started, and of parts of the administered Yucca saponin were performed. The Yucca material contained mainly sarsasapogenin and smilagenin saponins. Ingested saponins were quickly hydrolysed in the rumen to free sapogenins and, in part, epimerized at C-3 to afford episapogenins. The absorption of free sapogenins appeared to occur in the jejunum. The metabolism of Yucca saponins was identical to that of Narthecium ossifragum saponins, and it is suggested that Yucca saponins could replace N. ossifragum saponins for toxicity studies on the latter plant.

Citing Articles

Chemistry, Biosynthesis and Pharmacology of Sarsasapogenin: A Potential Natural Steroid Molecule for New Drug Design, Development and Therapy.

Mustafa N, Sekar M, Fuloria S, Begum M, Gan S, Mat Rani N Molecules. 2022; 27(6).

PMID: 35335393 PMC: 8955086. DOI: 10.3390/molecules27062032.

Saponin-Induced Shifts in the Rumen Microbiome and Metabolome of Young Cattle.

Wang B, Ma M, Diao Q, Tu Y Front Microbiol. 2019; 10:356.

PMID: 30873143 PMC: 6403146. DOI: 10.3389/fmicb.2019.00356.

References

Flaoyen A, Smith B, Miles C . An attempt to reproduce crystal-associated cholangitis in lambs in experimental dosing of sarsasapogenin or diosgenin alone and in combination with sporidesmin. N Z Vet J. 1993; 41(4):171-4. DOI: 10.1080/00480169.1993.35764. View

Smith B, Miles C . A role for Brachiaria decumbens in hepatogenous photosensitization of ruminants?. Vet Hum Toxicol. 1993; 35(3):256-7. View

Hristov A, McAllister T, Van Herk F, Cheng K, Newbold C, Cheeke P . Effect of Yucca schidigera on ruminal fermentation and nutrient digestion in heifers. J Anim Sci. 1999; 77(9):2554-63. DOI: 10.2527/1999.7792554x. View

Langseth W, Torgersen T, Kolsaker P, Romming C, Jantsch T, Mantle P . Isolation and characterization of 3-methoxy-2(5H)-furanone as the principal nephrotoxin from Narthecium ossifragum (L.) Huds. Nat Toxins. 2000; 7(3):111-8. DOI: 10.1002/(sici)1522-7189(199905/06)7:3<111::aid-nt48>3.0.co;2-f. View

Cheeke P . Biological effects of feed and forage saponins and their impacts on animal production. Adv Exp Med Biol. 1996; 405:377-85. DOI: 10.1007/978-1-4613-0413-5_32. View

CEH L, HAUGE J . Alveld-producing saponins. I. Chemical studies. Acta Vet Scand. 1981; 22(3-4):391-402. PMC: 8300470. View

Wang Y, McAllister T, Yanke L, Cheeke P . Effect of steroidal saponin from Yucca schidigera extract on ruminal microbes. J Appl Microbiol. 2000; 88(5):887-96. DOI: 10.1046/j.1365-2672.2000.01054.x. View

Flaoyen A, Wilkins A, Deng D, Brekke T . Ovine metabolism of saponins: evaluation of a method for estimating the ovine uptake of steroidal saponins from Narthecium ossifragum. Vet Res Commun. 2001; 25(3):225-38. DOI: 10.1023/a:1006485726523. View

Patamalai B, Hejtmancik E, Bridges C, Hill D, Camp B . The isolation and identification of steroidal sapogenins in Kleingrass. Vet Hum Toxicol. 1990; 32(4):314-8. View

10.

Kellerman T, Erasmus G, Coetzer J, Brown J, Maartens B . Photosensitivity in South Africa. VI. The experimental induction of geeldikkop in sheep with crude steroidal saponins from Tribulus terrestris. Onderstepoort J Vet Res. 1991; 58(1):47-53. View

11.

Flaoyen A, Hove K, Wilkins A . Tolerance to the nephrotoxic component of Narthecium ossifragum in sheep: the effects of repeated oral doses of plant extracts. Vet Res Commun. 2001; 25(2):127-36. DOI: 10.1023/a:1006456919052. View

12.

Flaoyen A, Bratberg B, Gronstol H . Nephrotoxicity in lambs apparently caused by experimental feeding with Narthecium ossifragum. Vet Res Commun. 1995; 19(1):75-9. DOI: 10.1007/BF01839254. View

13.

Flaoyen A, Wilkins A . Metabolism of saponins from Narthecium ossifragum--a plant implicated in the aetiology of alveld, a hepatogenous photosensitization of sheep. Vet Res Commun. 1997; 21(5):335-45. DOI: 10.1023/a:1005860220462. View

14.

Miles C, Wilkins A, Erasmus G, Kellerman T . Photosensitivity in South Africa. VIII. Ovine metabolism of Tribulus terrestris saponins during experimentally induced geeldikkop. Onderstepoort J Vet Res. 1994; 61(4):351-9. View

15.

Miyakoshi M, Tamura Y, Masuda H, Mizutani K, Tanaka O, Ikeda T . Antiyeast steroidal saponins from Yucca schidigera (Mohave yucca), a new anti-food-deteriorating agent. J Nat Prod. 2000; 63(3):332-8. DOI: 10.1021/np9904354. View

16.

Flaoyen A . Do steroidal saponins have a role in hepatogenous photosensitization diseases of sheep?. Adv Exp Med Biol. 1996; 405:395-403. DOI: 10.1007/978-1-4613-0413-5_34. View

17.

Flaoyen A, Tonnesen H, Gronstol H, Karlsen J . Failure to induce toxicity in lambs by administering saponins from Narthecium ossifragum. Vet Res Commun. 1991; 15(6):483-7. DOI: 10.1007/BF00346548. View

18.

Videm Abdelkader S, CEH L, Dishington I, HAUGE J . Alveld-producing saponins. II. Toxicological studies. Acta Vet Scand. 1984; 25(1):76-85. PMC: 8287452. View