Vav3 is Regulated During the Cell Cycle and Effects Cell Division

Overview

Journal Proc Natl Acad Sci U S A

Specialty Science

Date 2002 Mar 28

PMID 11917103

Citations 13

Authors

Keiko Fujikawa

Yoshiro Inoue

Masaharu Sakai

Yoshikazu Koyama

Shinzo Nishi

Ryo Funada

Frederick W Alt

Wojciech Swat

Affiliations

Soon will be listed here.

Abstract

Vav3 is a member of the family of guanine nucleotide exchange factors implicated in the regulation of Rho GTPases. Although the exact in vivo function of Vav3 is unknown, evidence from several studies indicates a role distinct from Vav2 or Vav1. Here we report that the expression of Vav3 is regulated during the cell cycle. Strikingly, Vav3 was transiently up-regulated in HeLa cells during mitosis, whereas enforced expression of Vav3 perturbed cytokinesis and led to the appearance of multinucleated cells. These effects of Vav3 were RhoA-dependent, required phosphorylation of the regulatory tyrosine 173, but were not enhanced by N-terminal truncations. Thus, this report establishes that expression of Vav3 is strictly regulated in a cell cycle-dependent manner and implicates Vav3 in the control of cytokinesis.

Citing Articles

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