The Contribution of Nuclear Compartmentalization to Gene Regulation

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2002 Mar 23

PMID 11909522

Citations 65

Authors

Maria Carmo-Fonseca

Affiliations

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Abstract

Recent developments in live-cell imaging are challenging our stereotyped view of the fixed cell nucleus. The emerging picture is that nuclear processes may rely on a constant flow of molecules between dynamic compartments created by relatively immobile binding or assembly sites. This article discusses current views on the origins of nuclear compartments and their roles in gene expression.

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