Intragastric Microbial Colonization in Common Disease States of the Stomach and Duodenum

Overview

Journal Ann Surg

Specialty General Surgery

Date 1975 Nov 1

PMID 1190860

Citations 10

Authors

R L Nichols

J W Smith

Affiliations

Soon will be listed here.

Abstract

Forty-nine patients undergoing elective or emergent gastric surgery have been included in this study. Gastric needle aspiration was performed at the time of surgery in each case, followed by qualitative aerobic and anaerobic bacteriologic analysis. In 18 patients undergoing elective operation for chronic nonobstructing duodenal ulcer a gastric microflora was present in only three patients and no postoperative wound infections were observed. In 29 of 31 patients, in the other groups of patients with bleeding or obstructing duodenal ulcer or in those with gastric ulcer or malignancy, intragastric micro-organisms were present. Six of the 7 postoperative wound infections which developed in these groups of patients were due to one of the same bacteria isolated at the time of original needle aspiration. It appears that the endogenous intragastric microflora is a significant factor in the development of postoperative wound sepsis following gastric resection, in those groups of patients with a compromise of their normal gastric antibacterial inhibitory mechanisms.

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References

BALLINGER 2nd W, Iida J, PADULA R, APONTE G, Wirts C, Goldstein F . BACTERIAL INFLAMMATION AND DENERVATION ATROPHY OF THE SMALL INTESTINE. Surgery. 1965; 57:535-41. View

DELLIPIANI A, Girdwood R . BACTERIAL CHANGES IN THE SMALL INTESTINE IN MALABSORPTIVE STATES AND IN PERNICIOUS ANAEMIA. Clin Sci. 1964; 26:359-74. View

SHINER M, WATERS T, GRAY J . CULTURE STUDIES OF THE GASTROINTESTINAL TRACT WITH A NEWLY DEVISED CAPSULE. RESULTS OF TESTS IN VITRO AND IN VIVO. Gastroenterology. 1963; 45:625-32. View

CREGAN J, HAYWARD N . The bacterial content of the healthy human small intestine. Br Med J. 1953; 1(4824):1356-9. PMC: 2016674. DOI: 10.1136/bmj.1.4824.1356. View

Frederiksen W, BRUUSGAARD A, Thaysen E . Assessment of the relationship between gastric secretory capacity and jejunal bacteriology. Scand J Gastroenterol. 1973; 8(4):353-9. View

Brooks J, Smith H, Pease Jr F . Bacteriology of the stomach immediately following vagotomy: the growth of Candida albicans. Ann Surg. 1974; 179(6):859-62. PMC: 1355915. DOI: 10.1097/00000658-197406000-00007. View

Giannella R, Broitman S, ZAMCHECK N . Gastric acid barrier to ingested microorganisms in man: studies in vivo and in vitro. Gut. 1972; 13(4):251-6. PMC: 1412163. DOI: 10.1136/gut.13.4.251. View

Browning G, Buchan K, MacKay C . The effect of vagotomy and drainage on the small bowel flora. Gut. 1974; 15(2):139-42. PMC: 1412897. DOI: 10.1136/gut.15.2.139. View

Nichols R, Broido P, Condon R, Gorbach S, Nyhus L . Effect of preoperative neomycin-erythromycin intestinal preparation on the incidence of infectious complications following colon surgery. Ann Surg. 1973; 178(4):453-62. PMC: 1355681. DOI: 10.1097/00000658-197310000-00008. View

10.

Broido P, Gorbach S, Condon R, Nyhus L . Upper intestinal microfloral control. Effects of gastric acid and vagal denervation on bacterial concentrations. Arch Surg. 1973; 106(1):90-3. DOI: 10.1001/archsurg.1973.01350130088020. View

11.

HERTER F . Preparation of the bowel for surgery. Surg Clin North Am. 1972; 52(4):859-70. DOI: 10.1016/s0039-6109(16)39785-7. View

12.

Polk Jr H, LOPEZ-MAYOR J . Postoperative wound infection: a prospective study of determinant factors and prevention. Surgery. 1969; 66(1):97-103. View

13.

GREENLEE H, Vivit R, Paez J, Dietz A . Bacterial flora of the jejunum following peptic ulcer surgery. Arch Surg. 1971; 102(4):260-5. DOI: 10.1001/archsurg.1971.01350040022005. View

14.

BORNSIDE G, COHN Jr I . The normal microbial flora: comparative bacterial flora of animals and man. Am J Dig Dis. 1965; 10(10):844-52. DOI: 10.1007/BF02236093. View

15.

Franklin M, Skoryna S . Studies on natural gastric flora. I. Bacterial flora of fasting human subjects. Can Med Assoc J. 1966; 95(26):1349-55. PMC: 1935882. View