Transplantation Tolerance from a Historical Perspective

Overview

Journal Nat Rev Immunol

Specialty Allergy & Immunology

Date 2002 Mar 22

PMID 11905833

Citations 56

Authors

T E Starzl

R M Zinkernagel

Affiliations

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Abstract

Although transplantation immunology as a distinctive field began with the development of experimental models that showed the feasibility of bone marrow transplantation, organ engraftment was accomplished first in humans, and was thought for many years to occur by drastically different mechanisms. Here, we present our view of the concepts of allograft acceptance and acquired tolerance from a historical perspective, and attempt to amalgamate them into simple and unifying rules that might guide improvements in clinical therapy.

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References

Michie D, Woodruff M, ZEISS I . An investigation of immunological tolerance based on chimaera analysis. Immunology. 1961; 4:413-24. PMC: 1424115. View

Thomson A, Lu L, Murase N, Demetris A, Rao A, Starzl T . Microchimerism, dendritic cell progenitors and transplantation tolerance. Stem Cells. 1995; 13(6):622-39. PMC: 2963943. DOI: 10.1002/stem.5530130607. View

Lechler R, Batchelor J . Restoration of immunogenicity to passenger cell-depleted kidney allografts by the addition of donor strain dendritic cells. J Exp Med. 1982; 155(1):31-41. PMC: 2186574. DOI: 10.1084/jem.155.1.31. View

Webb S, Morris C, Sprent J . Extrathymic tolerance of mature T cells: clonal elimination as a consequence of immunity. Cell. 1990; 63(6):1249-56. DOI: 10.1016/0092-8674(90)90420-j. View

STONE H, Owings J, GEY G . TRANSPLANTATION OF LIVING GRAFTS OF THYROID AND PARATHYROID GLANDS. Ann Surg. 1934; 100(4):613-28. PMC: 1390416. DOI: 10.1097/00000658-193410000-00005. View

KUSS R, LEGRAIN M, MATHE G, NEDEY R, CAMEY M . Homologous human kidney transplantation. Experience with six patients. Postgrad Med J. 1962; 38:528-31. PMC: 2482104. DOI: 10.1136/pgmj.38.443.528. View

Monaco A, CLARK A, Wood M, Sahyoun A, Codish S, Brown R . Possible active enhancement of a human cadaver renal allograft with antilymphocyte serum (ALS) and donor bone marrow: case report of an initial attempt. Surgery. 1976; 79(4):384-92. View

STERZL J, Silverstein A . Developmental aspects of immunity. Adv Immunol. 1967; 6:337-459. DOI: 10.1016/s0065-2776(08)60525-8. View

Schwartz R, DAMESHEK W . Drug-induced immunological tolerance. Nature. 1959; 183(4676):1682-3. DOI: 10.1038/1831682a0. View

10.

Barker C, Billingham R . The role of afferent lymphatics in the rejection of skin homografts. J Exp Med. 1968; 128(1):197-221. PMC: 2138504. DOI: 10.1084/jem.128.1.197. View

11.

Ichikawa N, Demetris A, Starzl T, Ye Q, Okuda T, Chun H . Donor and recipient leukocytes in organ allografts of recipients with variable donor-specific tolerance: with particular reference to chronic rejection. Liver Transpl. 2000; 6(6):686-702. PMC: 3091393. DOI: 10.1053/jlts.2000.19029. View

12.

Starzl T, Marchioro T, Porter K, Iwasaki Y, CERILLI G . The use of heterologous antilymphoid agents in canine renal and liver homotransplantation and in human renal homotransplantation. Surg Gynecol Obstet. 1967; 124(2):301-8. PMC: 2675827. View

13.

Thomas E, Storb R, Clift R, Fefer A, Johnson L, Neiman P . Bone-marrow transplantation (second of two parts). N Engl J Med. 1975; 292(17):895-902. DOI: 10.1056/NEJM197504242921706. View

14.

Zinkernagel R . Immunology taught by viruses. Science. 1996; 271(5246):173-8. DOI: 10.1126/science.271.5246.173. View

15.

Hamburger J, Vaysse J, CROSNIER J, AUVERT J, LALANNE C, HOPPER Jr J . Renal homotransplantation in man after radiation of the recipient. Experience with six patients since 1959. Am J Med. 1962; 32:854-71. DOI: 10.1016/0002-9343(62)90032-3. View

16.

Starzl T, Demetris A, Murase N, Ildstad S, Ricordi C, Trucco M . Cell migration, chimerism, and graft acceptance. Lancet. 1992; 339(8809):1579-82. PMC: 2950640. DOI: 10.1016/0140-6736(92)91840-5. View

17.

Starzl T, Demetris A, Trucco M, Murase N, Ricordi C, Ildstad S . Cell migration and chimerism after whole-organ transplantation: the basis of graft acceptance. Hepatology. 1993; 17(6):1127-52. PMC: 2964270. View

18.

Waldmann H . Transplantation tolerance-where do we stand?. Nat Med. 1999; 5(11):1245-8. DOI: 10.1038/15197. View

19.

Zinkernagel R, Ehl S, Aichele P, Oehen S, Kundig T, Hengartner H . Antigen localisation regulates immune responses in a dose- and time-dependent fashion: a geographical view of immune reactivity. Immunol Rev. 1997; 156:199-209. DOI: 10.1111/j.1600-065x.1997.tb00969.x. View

20.

Takatsuki M, Uemoto S, Inomata Y, Egawa H, Kiuchi T, Fujita S . Weaning of immunosuppression in living donor liver transplant recipients. Transplantation. 2001; 72(3):449-54. DOI: 10.1097/00007890-200108150-00016. View