Rescuing the Function of Mutant P53

Overview

Journal Nat Rev Cancer

Specialty Oncology

Date 2002 Mar 20

PMID 11900253

Citations 210

Authors

A N Bullock

A R Fersht

Affiliations

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Abstract

One protein--p53--plays nemesis to most cancers by condemning damaged cells to death or quarantining them for repair. But the activity of p53 relies on its intact native conformation, which can be lost following mutation of a single nucleotide. With thousands of such mutations identified in patients, how can a future cancer drug buttress this fragile protein structure and restore the cell's natural defence?

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