Influence of SHIP on the NK Repertoire and Allogeneic Bone Marrow Transplantation

Overview

Journal Science

Specialty Science

Date 2002 Mar 16

PMID 11896280

Citations 67

Authors

Jia-Wang Wang

Julie M Howson

Tomar Ghansah

Caroline Desponts

John M Ninos

Sarah L May

Kim H T Nguyen

Noriko Toyama-Sorimachi

William G Kerr

Affiliations

Soon will be listed here.

Abstract

Natural killer cell (NK) receptors for major histocompatibility complex (MHC) class I influence engraftment and graft-versus-tumor effects after allogeneic bone marrow transplantation. We find that SH2-containing inositol phosphatase (SHIP) influences the repertoire of NK receptors. In adult SHIP-/- mice, the NK compartment is dominated by cells that express two inhibitory receptors capable of binding either self or allogeneic MHC ligands. This promiscuous repertoire has significant functional consequences, because SHIP-/- mice fail to reject fully mismatched allogeneic marrow grafts and show enhanced survival after such transplants. Thus, SHIP plays an important role in two processes that limit the success of allogeneic marrow transplantation: graft rejection and graft-versus-host disease.

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