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Histone Modifications in Transcriptional Regulation

Overview
Publisher Elsevier
Specialties Biology
Genetics
Date 2002 Mar 15
PMID 11893486
Citations 450
Authors
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Abstract

Covalent modifications of the amino termini of the core histones in nucleosomes have important roles in gene regulation. Research in the past two years reveals these modifications to consist of phosphorylation, methylation and ubiquitination, in addition to the better-characterized acetylation. This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues persuasively for the existence of a histone code.

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