Basophils in Airway Disease

Overview

Journal Curr Allergy Asthma Rep

Specialties Allergy & Immunology
Pulmonary Medicine

Date 2002 Mar 15

PMID 11892092

Citations 2

Authors

Donald MacGlashan Jr

Gail Gauvreau

John T Schroeder

Affiliations

Soon will be listed here.

Abstract

The inflammatory response that is often associated with asthma is characterized by the recruitment of eosinophils, basophils, and lymphocytes. Until recently, profiling the basophil and defining its functional characteristics have been difficult. With the advent of some new tools, there is a steadily increasing body of information on the presence and potential activities of the basophil. Although the precise role of these cells in airway diseases, such as asthma, remain unclear, relatively accurate enumeration is now possible. Coupled with new insights into cytokine secretion from these cells, a more accurate picture of the dynamics of this specialized form of inflammation is available for refining our hypotheses regarding its regulation.

Citing Articles

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References

Devouassoux G, Foster B, Scott L, Metcalfe D, Prussin C . Frequency and characterization of antigen-specific IL-4- and IL-13- producing basophils and T cells in peripheral blood of healthy and asthmatic subjects. J Allergy Clin Immunol. 1999; 104(4 Pt 1):811-9. DOI: 10.1016/s0091-6749(99)70292-7. View

Pizzichini E, Pizzichini M, Efthimiadis A, Evans S, Morris M, Squillace D . Indices of airway inflammation in induced sputum: reproducibility and validity of cell and fluid-phase measurements. Am J Respir Crit Care Med. 1996; 154(2 Pt 1):308-17. DOI: 10.1164/ajrccm.154.2.8756799. View

Iliopoulos O, Baroody F, Naclerio R, Bochner B, Lichtenstein L . Histamine-containing cells obtained from the nose hours after antigen challenge have functional and phenotypic characteristics of basophils. J Immunol. 1992; 148(7):2223-8. View

Kasaian M, Clay M, Happ M, Garman R, Hirani S, Luqman M . IL-4 production by allergen-stimulated primary cultures: identification of basophils as the major IL-4-producing cell type. Int Immunol. 1996; 8(8):1287-97. DOI: 10.1093/intimm/8.8.1287. View

Ying S, Robinson D, Meng Q, Barata L, McEUEN A, Buckley M . C-C chemokines in allergen-induced late-phase cutaneous responses in atopic subjects: association of eotaxin with early 6-hour eosinophils, and of eotaxin-2 and monocyte chemoattractant protein-4 with the later 24-hour tissue eosinophilia, and.... J Immunol. 1999; 163(7):3976-84. View

Gauvreau G, Lee J, Watson R, Irani A, Schwartz L, OByrne P . Increased numbers of both airway basophils and mast cells in sputum after allergen inhalation challenge of atopic asthmatics. Am J Respir Crit Care Med. 2000; 161(5):1473-8. DOI: 10.1164/ajrccm.161.5.9908090. View

Ying S, Humbert M, Barkans J, Corrigan C, Pfister R, Menz G . Expression of IL-4 and IL-5 mRNA and protein product by CD4+ and CD8+ T cells, eosinophils, and mast cells in bronchial biopsies obtained from atopic and nonatopic (intrinsic) asthmatics. J Immunol. 1997; 158(7):3539-44. View

Li Y, Li L, Wadley R, Reddel S, Qi J, Archis C . Mast cells/basophils in the peripheral blood of allergic individuals who are HIV-1 susceptible due to their surface expression of CD4 and the chemokine receptors CCR3, CCR5, and CXCR4. Blood. 2001; 97(11):3484-90. DOI: 10.1182/blood.v97.11.3484. View

Fahy J, Wong H, Liu J, Boushey H . Comparison of samples collected by sputum induction and bronchoscopy from asthmatic and healthy subjects. Am J Respir Crit Care Med. 1995; 152(1):53-8. DOI: 10.1164/ajrccm.152.1.7599862. View

10.

Maruyama N, Tamura G, Aizawa T, Ohrui T, Shimura S, Shirato K . Accumulation of basophils and their chemotactic activity in the airways during natural airway narrowing in asthmatic individuals. Am J Respir Crit Care Med. 1994; 150(4):1086-93. DOI: 10.1164/ajrccm.150.4.7921441. View

11.

Irani A, Huang C, Xia H, Kepley C, Nafie A, Fouda E . Immunohistochemical detection of human basophils in late-phase skin reactions. J Allergy Clin Immunol. 1998; 101(3):354-62. DOI: 10.1016/S0091-6749(98)70248-9. View

12.

Wilson S, Shute J, Holgate S, Howarth P, Bradding P . Localization of interleukin (IL) -4 but not IL-5 to human mast cell secretory granules by immunoelectron microscopy. Clin Exp Allergy. 2000; 30(4):493-500. DOI: 10.1046/j.1365-2222.2000.00756.x. View

13.

Pawankar R, Okuda M, Yssel H, Okumura K, Ra C . Nasal mast cells in perennial allergic rhinitics exhibit increased expression of the Fc epsilonRI, CD40L, IL-4, and IL-13, and can induce IgE synthesis in B cells. J Clin Invest. 1997; 99(7):1492-9. PMC: 507968. DOI: 10.1172/JCI119311. View

14.

Kay A, Ying S, Varney V, Gaga M, Durham S, Moqbel R . Messenger RNA expression of the cytokine gene cluster, interleukin 3 (IL-3), IL-4, IL-5, and granulocyte/macrophage colony-stimulating factor, in allergen-induced late-phase cutaneous reactions in atopic subjects. J Exp Med. 1991; 173(3):775-8. PMC: 2118805. DOI: 10.1084/jem.173.3.775. View

15.

Bascom R, PIPKORN U, Lichtenstein L, Naclerio R . The influx of inflammatory cells into nasal washings during the late response to antigen challenge. Effect of systemic steroid pretreatment. Am Rev Respir Dis. 1988; 138(2):406-12. DOI: 10.1164/ajrccm/138.2.406. View

16.

McEUEN A, Calafat J, Compton S, Easom N, Buckley M, Knol E . Mass, charge, and subcellular localization of a unique secretory product identified by the basophil-specific antibody BB1. J Allergy Clin Immunol. 2001; 107(5):842-8. DOI: 10.1067/mai.2001.114650. View

17.

Maestrelli P, Saetta M, Di Stefano A, Calcagni P, Turato G, Ruggieri M . Comparison of leukocyte counts in sputum, bronchial biopsies, and bronchoalveolar lavage. Am J Respir Crit Care Med. 1995; 152(6 Pt 1):1926-31. DOI: 10.1164/ajrccm.152.6.8520757. View

18.

Koshino T, Arai Y, Miyamoto Y, Sano Y, Itami M, Teshima S . Airway basophil and mast cell density in patients with bronchial asthma: relationship to bronchial hyperresponsiveness. J Asthma. 1996; 33(2):89-95. DOI: 10.3109/02770909609054536. View

19.

Pin I, Gibson P, Kolendowicz R, Girgis-Gabardo A, Denburg J, Hargreave F . Use of induced sputum cell counts to investigate airway inflammation in asthma. Thorax. 1992; 47(1):25-9. PMC: 463545. DOI: 10.1136/thx.47.1.25. View

20.

Koshino T, Teshima S, Fukushima N, Takaishi T, Hirai K, Miyamoto Y . Identification of basophils by immunohistochemistry in the airways of post-mortem cases of fatal asthma. Clin Exp Allergy. 1993; 23(11):919-25. DOI: 10.1111/j.1365-2222.1993.tb00276.x. View