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Ion Transport Proteins Anchor and Regulate the Cytoskeleton

Overview
Publisher Elsevier
Specialty Cell Biology
Date 2002 Mar 14
PMID 11891121
Citations 45
Authors
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Abstract

Structurally diverse ion transport proteins anchor the spectrin-actin cytoskeleton to the plasma membrane by binding directly to linker proteins of the ankyrin and protein 4.1 families. Cytoskeletal anchoring regulates cell shape and restricts the activity of ion transport proteins to specialised membrane domains. New directions are being forged by recent findings that localised anchoring by ion transport proteins regulates the ordered assembly of actin filaments and the actin-dependent processes of cell adhesion and motility.

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