Potentiation and Prolongation of the Insulinotropic Action of Glucagon-like Peptide 1 by Methyl Pyruvate or Dimethyl Ester of L-glutamic Acid in a Type 2 Diabetes Animal Model

Overview

Journal Endocrine

Specialty Endocrinology

Date 2002 Mar 13

PMID 11887931

Authors

J Cancelas

M L Villanueva-Penacarrillo

I Valverde

W J Malaisse

Affiliations

Soon will be listed here.

Abstract

Methyl pyruvate and the dimethyl ester of L-glutamic acid were administered intravenously, as a primed constant infusion (1.0-2.0 micromol followed by 0.5-1.0 micromol/min, both expressed per gram of body wt), in adult rats that had been injected with streptozotocin during the neonatal period. Each ester augmented plasma insulin concentration and potentiated and/or prolonged the insulinotropic action of glucagon-like peptide 1 (GLP-1) injected intravenously (5 pmol/g of body wt) at min 5 of the test. It is proposed, therefore, that suitable nonglucidic nutrients, susceptible to bypassing the site-specific defects of D-glucose transport and metabolism responsible for the preferential impairment of the B-cell secretory response to D-glucose in non-insulin-dependent diabetes, could be used to optimize the insulinotropic action of GLP-1.

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