The Prevalence of Autoantibodies in an Elderly Sub-Saharan African Population

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 2002 Mar 8

PMID 11882039

Citations 14

Authors

R Njemini

I Meyers

C Demanet

J Smitz

M Sosso

T Mets

Affiliations

Soon will be listed here.

Abstract

In the present prospective, census-based study we have investigated the prevalence of organ-specific and non-organ-specific autoantibodies (AAb) in 152 unselected Cameroonians aged 60 years and older living in the community. AAb were detected in 49% of the participants. Non-organ-specific AAb (47%) predominated over organ-specific AAb (7%). Anti-TPO, anti-Tm, anti-Tg and anti-PC AAb were completely absent. RF was the most frequent AAb, being found in 57 (38%) cases. The prevalences of anti-SMA and RF were significantly higher in women than in men (respectively, P=0.023 and P=0.016). Higher serum concentrations of gammaglobulins were accompanied by a higher prevalence of RF (P < 0.0001) and a lower prevalence of ANA (P=0.036). The overall prevalence of AAb was higher in the filaria-infected (60%) compared to the non-infected (42%) participants (P=0.046). There was no significant influence of the vitamin D status, number of pregnancies, physical activity or medication use on the prevalence of AAb. In this study a heterogeneous pattern for the presence of the various AAb was found. Some AAb, which are commonly encountered in other studies on elderly subjects, were completely absent in this population. This diversified pattern of AAb prevalence therefore argues in favour of exogenous influences in the occurrence of AAb in elderly populations.

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References

Green T, Packer B . A role for rheumatoid factor enhancement of Plasmodium falciparum schizont inhibition in vitro. Infect Immun. 1984; 46(3):668-72. PMC: 261594. DOI: 10.1128/iai.46.3.668-672.1984. View

Hackett E, BEECH M, FORBES I . Thyrogloubulin antibodies in patients without clinical disease of the thyroid gland. Lancet. 1960; 2(7147):402-4. DOI: 10.1016/s0140-6736(60)92842-7. View

Cooper B, Fehedy V, Blanshay P . Recognition of deficiency of vitamin B12 using measurement of serum concentration. J Lab Clin Med. 1986; 107(5):447-52. View

Antonaci S, Jirillo E, BONOMO L . Immunoregulation in aging. Diagn Clin Immunol. 1987; 5(2):55-61. View

Manoussakis M, Tzioufas A, Silis M, Pange P, Goudevenos J, Moutsopoulos H . High prevalence of anti-cardiolipin and other autoantibodies in a healthy elderly population. Clin Exp Immunol. 1987; 69(3):557-65. PMC: 1542366. View

Nutman T, Reese W, Poindexter R, Ottesen E . Immunologic correlates of the hyperresponsive syndrome of loiasis. J Infect Dis. 1988; 157(3):544-50. DOI: 10.1093/infdis/157.3.544. View

Fields R, Toubbeh H, Searles R, Bankhurst A . The prevalence of anticardiolipin antibodies in a healthy elderly population and its association with antinuclear antibodies. J Rheumatol. 1989; 16(5):623-5. View

Ruffatti A, Rossi L, Calligaro A, Del Ross T, Lagni M, Marson P . Autoantibodies of systemic rheumatic diseases in the healthy elderly. Gerontology. 1990; 36(2):104-11. DOI: 10.1159/000213183. View

Chakravarty K, Gray R, Webley M, Byron M, Wozniak J . Prevalence of anticardiolipin antibodies in the elderly British population. Postgrad Med J. 1991; 67(786):358-61. PMC: 2398833. DOI: 10.1136/pgmj.67.786.358. View

10.

Manoussakis M, Stavropoulos E, Germanidis G, Papasteriades C, Garalea K, Dontas A . Soluble interleukin-2 receptors and autoantibodies in the serum of healthy elderly individuals. Autoimmunity. 1990; 7(2-3):129-37. DOI: 10.3109/08916939008993385. View

11.

Talor E, Rose N . Hypothesis: the aging paradox and autoimmune disease. Autoimmunity. 1991; 8(3):245-9. DOI: 10.3109/08916939108997112. View

12.

Tomer Y, Shoenfeld Y . Ageing and autoantibodies. Autoimmunity. 1988; 1(2):141-9. DOI: 10.3109/08916938809001927. View

13.

Bhatia A, Vinayak V . Dietary modulation of malaria infection in rats. Indian J Malariol. 1991; 28(4):237-42. View

14.

Perez L, Rodriguez C, Sepulveda J, Silva M . [Autoimmune phenomena in the elderly]. Rev Med Chil. 1991; 119(3):287-92. View

15.

Rolland L, Ballet J . Kinetics of antigen specific and non-specific polyclonal B-cell responses during lethal Plasmodium yoelii malaria. Mem Inst Oswaldo Cruz. 1992; 87(2):197-204. DOI: 10.1590/s0074-02761992000200005. View

16.

Mets T . The disease pattern of elderly medical patients in Rwanda, central Africa. J Trop Med Hyg. 1993; 96(5):291-300. View

17.

Fernandes G . Dietary lipids and risk of autoimmune disease. Clin Immunol Immunopathol. 1994; 72(2):193-7. DOI: 10.1006/clin.1994.1129. View

18.

Elson L, Shaw S, van Lier R, Nutman T . T cell subpopulation phenotypes in filarial infections: CD27 negativity defines a population greatly enriched for Th2 cells. Int Immunol. 1994; 6(7):1003-9. DOI: 10.1093/intimm/6.7.1003. View

19.

Rose N . Thymus function, ageing and autoimmunity. Immunol Lett. 1994; 40(3):225-30. DOI: 10.1016/0165-2478(94)00060-3. View

20.

Xavier R, Yamauchi Y, Nakamura M, Tanigawa Y, Ishikura H, Tsunematsu T . Antinuclear antibodies in healthy aging people: a prospective study. Mech Ageing Dev. 1995; 78(2):145-54. DOI: 10.1016/0047-6374(94)01532-q. View