Multiple Subunits of the Caenorhabditis Elegans Anaphase-promoting Complex Are Required for Chromosome Segregation During Meiosis I

Overview

Journal Genetics

Publisher Oxford University Press

Specialty Genetics

Date 2002 Feb 28

PMID 11861581

Citations 35

Authors

Edward S Davis

Lucia Wille

Barry A Chestnut

Penny L Sadler

Diane C Shakes

Andy Golden

Affiliations

Soon will be listed here.

Abstract

Two genes, originally identified in genetic screens for Caenorhabditis elegans mutants that arrest in metaphase of meiosis I, prove to encode subunits of the anaphase-promoting complex or cyclosome (APC/C). RNA interference studies reveal that these and other APC/C subunits are essential for the segregation of chromosomal homologs during meiosis I. Further, chromosome segregation during meiosis I requires APC/C functions in addition to the release of sister chromatid cohesion.

Citing Articles

Identification and sequencing of temperature sensitive alleles of the Anaphase Promoting Complex component in .

Maniates K, Zuo Y, Flanagan K, Halim S, Kane A, Singson A MicroPubl Biol. 2023; 2023.

PMID: 37614776 PMC: 10442702. DOI: 10.17912/micropub.biology.000889.

The APC/C Complex Coordinates With OMA-1 to Regulate the Oocyte-to-Embryo Transition in .

Hu Y, Hu X, Li D, Du Z, Shi K, He C Front Cell Dev Biol. 2021; 9:749654.

PMID: 34722532 PMC: 8554129. DOI: 10.3389/fcell.2021.749654.

Developmental Control of the Cell Cycle: Insights from .

Kipreos E, van den Heuvel S Genetics. 2019; 211(3):797-829.

PMID: 30846544 PMC: 6404260. DOI: 10.1534/genetics.118.301643.

oocytes detect meiotic errors in the absence of canonical end-on kinetochore attachments.

Davis-Roca A, Muscat C, Wignall S J Cell Biol. 2017; 216(5):1243-1253.

PMID: 28356326 PMC: 5412562. DOI: 10.1083/jcb.201608042.

Regulation of the MEI-1/MEI-2 Microtubule-Severing Katanin Complex in Early Caenorhabditis elegans Development.

Beard S, Smit R, Chan B, Mains P G3 (Bethesda). 2016; 6(10):3257-3268.

PMID: 27527792 PMC: 5068946. DOI: 10.1534/g3.116.031666.

References

Zhao N, Lai F, Fernald A, Eisenbart J, Espinosa R, Wang P . Human CDC23: cDNA cloning, mapping to 5q31, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. Genomics. 1998; 53(2):184-90. DOI: 10.1006/geno.1998.5473. View

Fire A, Xu S, Montgomery M, Kostas S, Driver S, Mello C . Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature. 1998; 391(6669):806-11. DOI: 10.1038/35888. View

Nasmyth K . Separating sister chromatids. Trends Biochem Sci. 1999; 24(3):98-104. DOI: 10.1016/s0968-0004(99)01358-4. View

Ohta T, Michel J, Schottelius A, Xiong Y . ROC1, a homolog of APC11, represents a family of cullin partners with an associated ubiquitin ligase activity. Mol Cell. 1999; 3(4):535-41. DOI: 10.1016/s1097-2765(00)80482-7. View

Uhlmann F, Lottspeich F, Nasmyth K . Sister-chromatid separation at anaphase onset is promoted by cleavage of the cohesin subunit Scc1. Nature. 1999; 400(6739):37-42. DOI: 10.1038/21831. View

Zachariae W, Nasmyth K . Whose end is destruction: cell division and the anaphase-promoting complex. Genes Dev. 1999; 13(16):2039-58. DOI: 10.1101/gad.13.16.2039. View

Krawchuk M, DeVeaux L, Wahls W . Meiotic chromosome dynamics dependent upon the rec8(+), rec10(+) and rec11(+) genes of the fission yeast Schizosaccharomyces pombe. Genetics. 1999; 153(1):57-68. PMC: 1460733. DOI: 10.1093/genetics/153.1.57. View

Blatch G, Lassle M . The tetratricopeptide repeat: a structural motif mediating protein-protein interactions. Bioessays. 1999; 21(11):932-9. DOI: 10.1002/(SICI)1521-1878(199911)21:11<932::AID-BIES5>3.0.CO;2-N. View

Yamashita Y, Nakaseko Y, Kumada K, Nakagawa T, Yanagida M . Fission yeast APC/cyclosome subunits, Cut20/Apc4 and Cut23/Apc8, in regulating metaphase-anaphase progression and cellular stress responses. Genes Cells. 1999; 4(8):445-63. DOI: 10.1046/j.1365-2443.1999.00274.x. View

10.

Kent W, Zahler A . The intronerator: exploring introns and alternative splicing in Caenorhabditis elegans. Nucleic Acids Res. 1999; 28(1):91-3. PMC: 102389. DOI: 10.1093/nar/28.1.91. View

11.

Furuta T, Tuck S, Kirchner J, Koch B, Auty R, Kitagawa R . EMB-30: an APC4 homologue required for metaphase-to-anaphase transitions during meiosis and mitosis in Caenorhabditis elegans. Mol Biol Cell. 2000; 11(4):1401-19. PMC: 14855. DOI: 10.1091/mbc.11.4.1401. View

12.

Leverson J, Joazeiro C, Page A, Huang H, Hieter P, Hunter T . The APC11 RING-H2 finger mediates E2-dependent ubiquitination. Mol Biol Cell. 2000; 11(7):2315-25. PMC: 14921. DOI: 10.1091/mbc.11.7.2315. View

13.

Funabiki H, Murray A . The Xenopus chromokinesin Xkid is essential for metaphase chromosome alignment and must be degraded to allow anaphase chromosome movement. Cell. 2000; 102(4):411-24. DOI: 10.1016/s0092-8674(00)00047-7. View

14.

Fraser A, Kamath R, Zipperlen P, Martinez-Campos M, Sohrmann M, Ahringer J . Functional genomic analysis of C. elegans chromosome I by systematic RNA interference. Nature. 2000; 408(6810):325-30. DOI: 10.1038/35042517. View

15.

Gonczy P, Echeverri C, Oegema K, Coulson A, Jones S, Copley R . Functional genomic analysis of cell division in C. elegans using RNAi of genes on chromosome III. Nature. 2000; 408(6810):331-6. DOI: 10.1038/35042526. View

16.

Golden A, Sadler P, Wallenfang M, Schumacher J, Hamill D, Bates G . Metaphase to anaphase (mat) transition-defective mutants in Caenorhabditis elegans. J Cell Biol. 2001; 151(7):1469-82. PMC: 2150685. DOI: 10.1083/jcb.151.7.1469. View

17.

Peter M, Castro A, Lorca T, Le Peuch C, Doree M, Labbe J . The APC is dispensable for first meiotic anaphase in Xenopus oocytes. Nat Cell Biol. 2001; 3(1):83-7. DOI: 10.1038/35050607. View

18.

Timmons L, Court D, Fire A . Ingestion of bacterially expressed dsRNAs can produce specific and potent genetic interference in Caenorhabditis elegans. Gene. 2001; 263(1-2):103-12. DOI: 10.1016/s0378-1119(00)00579-5. View

19.

Maeda I, Kohara Y, Yamamoto M, Sugimoto A . Large-scale analysis of gene function in Caenorhabditis elegans by high-throughput RNAi. Curr Biol. 2001; 11(3):171-6. DOI: 10.1016/s0960-9822(01)00052-5. View

20.

Parry D, Ofarrell P . The schedule of destruction of three mitotic cyclins can dictate the timing of events during exit from mitosis. Curr Biol. 2001; 11(9):671-83. PMC: 2875931. DOI: 10.1016/s0960-9822(01)00204-4. View