Inhibition of Heat Shock-induced Apoptosis by Peppermint Oil in Astrocytes

Overview

Journal J Mol Neurosci

Specialties Molecular Biology
Neurology

Date 2002 Feb 28

PMID 11859935

Citations 1

Authors

H N Koo

H J Jeong

C H Kim

S T Park

S J Lee

K K Seong

S K Lee

Y S Lyu

H M Kim

Affiliations

Soon will be listed here.

Abstract

Exposure to environmental stresses and toxins is linked to the pathogenesis of neuropsychiatric disorders. Astrocytes, the most abundant glial-cell type in the brain, are considered to have physiological and pathological roles in neuronal activities. We have investigated whether peppermint oil inhibits heat shock-induced apoptosis of astrocytes. We found that peppermint oil inhibits the heat shock-induced apoptosis in both human astrocyte CCF-STTG1 cells and rat astrocytes. Pretreatment of the cells with peppermint oil inhibited the heat shock-induced DNA fragmentation and condensation of nuclear chromatin. Peppermint oil also inhibited the caspase-3 activation and poly-ADP-ribose polymerase fragmentation in CCF-STTG1 cells. These results suggest that peppermint oil may modulate the apoptosis of astrocytes via the activation of the caspase-3.

Citing Articles

Predictive Value of Odor Identification for Incident Dementia: The Shanghai Aging Study.

Ding D, Xiao Z, Liang X, Wu W, Zhao Q, Cao Y Front Aging Neurosci. 2020; 12:266.

PMID: 33005146 PMC: 7479092. DOI: 10.3389/fnagi.2020.00266.

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