The Mouse: Genetics Meets Behaviour

Overview

Journal Nat Rev Genet

Specialty Genetics

Date 2002 Feb 12

PMID 11836505

Citations 59

Authors

Maja Bucan

Ted Abel

Affiliations

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Abstract

Genetic studies in the mouse are important in the elucidation of molecular pathways that underlie behaviour. The advantages of the mouse for behavioural studies include an extensive array of genetic technologies and an elaborate behavioural repertoire that can be used to create models of human disease. This review discusses the relative advantages of forward and reverse genetic approaches to studying the genetic basis of behaviour in the mouse, and the complexities that behavioural studies need to address, such as phenotypic variability, genetic background effects and pleiotropy.

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