Effects of Intensive Application of Retinoic Acid on Human Skin

Overview

Journal Br J Dermatol

Publisher Oxford University Press

Specialty Dermatology

Date 1975 Jun 1

PMID 1182085

Citations 3

Authors

K H Kaidbey

A M Kligman

H Yoshida

Affiliations

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Abstract

The daily application of 0-3% retinoic acid to the back produced an acute irritant dermatitis which resolved to a near-normal clinical appearance within 40 days despite continued daily exposure. Hardened skin was markedly altered physiologically. The responses to DMSO, histamine and the histamine liberator, compound 48/80, were sharply enhanced. This reflected enhanced permeability resulting from reduction of the horny layer to less than one-half its normal thickness. Phototoxic and irritant substances produced exaggerated reactions owing to greater penetration. A paradoxical decrease in delayed sinsitivity to streptodornase-streptokinase was attributed to enhanced clearance of the antigen.

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Current status of topical tretinoin in the treatment of photoaged skin.

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Influences of retinoic acid and retinoid on skin metabolism. Investigations of oxygen consumption and enzymatic activities of human skin.

RAAB W, Gmeiner B Arch Dermatol Res (1975). 1976; 256(3):247-54.

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Vitamin A acid: a review of its pharmacological properties and therapeutic use in the topical treatment of acne vulgaris.

Heel R, Brogden R, Speight T, Avery G Drugs. 1977; 14(6):401-19.

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