A Comparison Between Previous and Present Histologic Assessments of Chronic Hepatitis C Viral Infections in Humans

Overview

Journal World J Gastroenterol

Publisher Baishideng Publishing Group

Specialty Gastroenterology

Date 2002 Jan 31

PMID 11819404

Citations 9

Authors

N Assy

Gy Minuk

Affiliations

Soon will be listed here.

Abstract

AIM:To compare the previously employed classification of liver histology (minimal,chronic persistent hepatitis, chronic active hepatitis and cirrhosis) with a new classification recently described by sheuer et al (activity grade and fibrosis stage) in percutaneous liver biopsies from patients with chronic hepatitis C viral infections.METHODS:Liver biopsies from 79 untreated patients were reviewed. Anti-HCV testing had been performed by ELISA and confirmed by a recombinant immunoblot assay.With respect to the new classification, all the specimens were evaluated using the Knodell score for activity.RESULTS:A good correlation was revealed between the previous and more recent histologic classifica-tions in patients with abnormal liver enzyme tests. However, in 13/15 (87%) of patients with normal aminotransferase values, changes were consistent with chronic persistent hepatitis whereas normal activity and no fibrosis were demonstrated by the Sheuer classifica-tion.CONCLUSION:The old classification is more often mislead-ing but correlates well with the new classification and thereby permits comparisons between historically clinical studies.

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